When it comes to shopping for topical products that keep fine lines and creases at bay, it’s important to keep expectations, shall we say, realistic. Though the best wrinkle fillers can keep the skin hydrated and pump between wrinkle-reducing procedures performed in-clinic, they are not replacements for injectables. However, they can work in tandem with Botox and fillers—and they also deliver smoothing benefits on their own, even for those who shudder at the thought of a needle.

Vogue’s Favorite Wrinkle Fillers:

• Best Drugstore: RoC Derm Correxion Fill + Treat Serum, $30
• Best Peptide Serum: SkinCeuticals P-Tiox, $148
• Best Wrinkle Patch: 111Skin Wrinkle Erasing Retinol Patches, $190
• Best Hyaluronic Acid Serum: Alastin Skincare HA Immerse Serum, $127
• Best for Growth Factors: SkinMedica TNS Advanced+ Serum, $295
• Best Ultra-Luxe: La Prairie Platinum Rare Haute-Rejuvenation Mask, $1,775
• Best for Refining Pores: DRMTLGY Needle-less Serum, $69
• Best for Under-Eye Wrinkles: Revision Skincare Revox Line Relaxer, $184
• Best Retinol Alternative: L’Oréal Paris Collagen Moisture Filler, $19

Kenneth Mark, FAAD, FACMS, a board-certified cosmetic dermatologist and injectables expert, likes to level the field for his patients before recommending the best wrinkle fillers to use at home. “Botox inhibits muscle movement to decrease wrinkles, while filler technology has evolved to produce dramatic, long-lasting, volume-enhancing, lifting and rejuvenating effects,” he says. “These results cannot be produced at home. The technology for fillers has evolved, and they no longer are just ‘fillers’ for lines, wrinkles, and lips as was the case 25 years ago. Now, we can literally add structure and definition and reshape and lift and contour the face.  You will not accomplish this with topical wrinkle fillers.”