It’s Week 5 and we’re into the first wave of bye weeks for the 2025 NFL season. That, coupled with injuries continuing to pile up, will make it more difficult to find players to plug into your lineup. As always, we’re going to be tracking all the latest NFL injury news throughout the week while providing some fantasy football analysis for the bigger names. Let’s get into it.

Week 4 injury recap

Malik Nabers, WR, Giants (knee): The nightmare scenario for the Giants came to life in Week 4 when Nabers tore his ACL on a play in the second quarter of a win over the Chargers. Nabers went up for a jump ball and came down grabbing his knee. With Nabers out for the season, rookie QB Jaxson Dart won’t have one of the best wideouts in the NFL at his disposal. Instead, he’ll have to operate with Wan’Dale Robinson, Darius Slayton and rookie RB Cam Skattebo the rest of the way.

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Lamar Jackson, QB, Ravens (hamstring): Jackson was forced to exit against the Chiefs in the second half in Week 4 and did not return. The Ravens were down big late in the third quarter and Cooper Rush took over at QB. While the game was a bit out of reach for Baltimore, this is still Jackson we’re talking about; if he was healthy enough to play, he’d be in there. We don’t know the extent of the injury so we’ll need more info before making any lineup calls. If Jackson is out in Week 5, it may be tough to trust the Ravens offense vs. the Texans. Receivers should be negatively affected while RB Derrick Henry would be leaned on heavily.

Ricky Pearsall/Jauan Jennings, WRs, 49ers: Both Pearsall and Jennings got banged up in Sunday’s game vs. the Jaguars. Jennings was able to return after taking a big hit. Pearsall left due to a knee injury and did not return. This has been a recurring theme all season with this receiver room. We’ll need to see how the practice week goes for both Pearsall and Jennings. It doesn’t help the Niners play the Rams on TNF. With the short week, San Fran could be shorthanded. TE Jake Tonges continues to take advantage of George Kittle’s absence. Tonges is an interesting add if the receivers can’t get healthy. Demarcus Robinson is the other wideout to consider off the wire.

CeeDee Lamb, WR, Cowboys (ankle): Lamb was expected to miss multiple weeks with a high-ankle sprain suffered in Week 3. He was out for SNF in Week 4 vs. the Packers. There’s a chance we see Lamb back at practice and he could make it back in time for Week 5 vs. the Jets.

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Jayden Daniels, QB, Commanders (knee): Daniels has missed the past two weeks but is expected to return in Week 5 vs. the Chargers. QB Marcus Mariota played well with Daniels sidelined considering Washington was also missing top WR Terry McLaurin (quad). It feels unlikely McLaurin is back for Week 5. If Daniels returns, he’s startable in all formats again and should be a boost for the offense overall.

Jaylen Warren, RB, Steelers (knee): Warren was a surprise inactive for Week 4 vs. the Vikings in Dublin. He was expected to play, per reports, but the Steelers decided to hold him out with the bye coming up. Pittsburgh will be back in action Week 6 vs. the Browns and we can expect Warren to be back as well. If he does end up missing more time, Kenneth Gainwell becomes a good RB2/FLEX play.

Week 5 injury report

Quarterback

• Lamar Jackson, Ravens (hamstring)

• Jayden Daniels, Commanders (knee)

• J.J. McCarthy, Vikings (ankle)

• Joe Burrow, Bengals (toe) — IR

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Running Back

• Jaylen Warren, Steelers (knee)

• Aaron Jones Sr., Vikings (hamstring) — IR

• Tyrone Tracy Jr., Giants (shoulder)

• Tyjae Spears, Titans (ankle) — IR

Wide Receiver

• CeeDee Lamb, Cowboys (ankle)

• Mike Evans, Bucs (hamstring)

• Ricky Pearsall, 49ers (knee)

• Jauan Jennings, 49ers (ribs)

• Terry McLaurin, Commanders (quad)

• Calvin Austin III, Steelers (shoulder)

• Darnell Mooney, Falcons (hamstring)

• Cedric Tillman, Browns (hamstring)

• Jalen Coker, Panthers (quad) — IR

• Alec Pierce, Colts (concussion)

• Dyami Brown, Jaguars (shoulder)

• Xavier Legette, Panthers (hamstring)

Tight End

• George Kittle, 49ers (hamstring) — IR

• Colston Loveland, Bears (hip)

• Ja’Tavion Sanders, Panthers (ankle)

• Michael Mayer, Raiders (concussion)

• Noah Fant, Broncos (concussion) — OUT in Week 4

Players done for the season

• Malik Nabers, Giants (knee)

• James Conner, Cardinals (foot)

• Najee Harris, Chargers (Achilles)